[5] The convention typically offers anime music videos, an art contest, artist alley, charity ball, cosplay chess, a dealer's room, fashion show, maid cafe, manga library, masquerade, movies, rave, tabletop gaming, and video game tournaments.

[7] Attendees who preregistered for Anime Milwaukee in 2013 could receive a discount for the Distant Worlds concert held the day before the convention on February 14, 2013.

In 2015, Anime Milwaukee's expected economic impact was over $1 million and it shared Wisconsin Center space with the Midwest Twisters Gymnastics Invitational.

[18][19] Anime Milwaukee had COVID-19 policies in 2022 that included mandatory masks, with ether vaccination or a negative test.

[20] Prior to Anime Milwaukee 2025, the burlesque show was cancelled due to online harassment involving performer applications.