She is known for co-starring roles in sitcoms The Jeff Foxworthy Show, Daddio, Shake It Up, The War at Home and Friends.
Barone also played Carol Willick, Ross Geller's ex-wife, in the character's first appearance in Friends.
She left the show as she wanted to pursue a more full-time role[4] and was replaced by Jane Sibbett.
Barone's other television credits include Curb Your Enthusiasm, Quantum Leap, Empty Nest, Chicago Hope, Castle, Do Not Disturb, Ally McBeal, Caroline in the City, Party of Five and The Larry Sanders Show.
In 2004, she was the recipient of the 2005 Methodfest Best Supporting Actress Award for her work in feature film, One Last Ride.