She is one of the most prominent models of the 20th and 21st century,[3][4] continuously featuring on magazine covers, as well as runways and campaigns for the most notable fashion houses.

[5] Rubik also plays a substantial role in supporting the women's rights movement as well as the LGBT+ community in Poland, as an activist and public speaker.

At the age of seventeen, Anja moved to Paris where she completed her education at a British high school, École Bilingue, and where she continued her modelling career.

[11] Rubik has also starred in campaigns for Armani, Balmain, Dante Herró, Chanel, Dior, Elie Saab, Estée Lauder, Givenchy, Hermès, Lanvin, Valentino, and Yves Saint Laurent.

In addition, Rubik has been the principal in campaigns for Barneys New York, Belstaff, BLK DNM, Bottega Veneta, DKNY, Etro, Dante Herró, Forever 21, Gap, H&M, Jimmy Choo, Karl by Karl Lagerfeld, Kurt Geiger, La Perla, Lacoste, Mango, Marc Jacobs, Moschino, Oscar de la Renta, Ralph Lauren, Roberto Cavalli, Seven Jeans, Tod's, Tommy Hilfiger, and Zara.

She was one of the three Poles, alongside Lech Wałęsa and John Paul II, who appeared on the cover of Time magazine, photographed by Ben Hassett.

Rubik has worked with photographers and artists, such as Annie Leibovitz, Araki, Camilla Akrans, David Bailey, David Sims, Collier Schorr, Inez van Lamsweerde and Vinoodh Matadin, Ellen von Unwerth, Glen Luchford, Hans Feurer, Hedi Slimane, Juergen Teller, JR, Mario Testino, Mario Sorrenti, Michael Thompson, Nick Knight, Patrick Demarchelier, Peter Lindbergh, Paolo Roversi, Steven Klein, Steven Meisel, and Terry Richardson.

[15] Rubik has become one of Karl Lagerfeld's most recognizable muses and helped launch the career of Yves Saint Laurent's Creative Director, Anthony Vaccarello; she continues to be the inspiration behind his designs.

[18] Contributors include Alex Prager, Araki, Ben Gorham, Carsten Holler, Daniel Arsham, Hedi Slimane, Isabel Marant, Inez and Vinoodh, JR, Marina Abramović, and Woodkid.

In September 2015, Rubik made her directorial debut by directing Issue 04's teaser film featuring Andreea Diaconu, themed around the five senses.

Art & Fashion Forum 2015 was the 9th edition of an event initiated by Grażyna Kulczyk, which is organized in Stary Browar in Poznań every year since 2007.

In 2022, Rubik became a global ambassador of French luxury jewelry and watch house Boucheron as part of its "Icons" campaign.

2014 also marks Rubik's appearance in the Black Atlass music video to the "Jewels" track, directed by Yoann Lemoine.

[29] In 2020, she lent her voice to one of the characters in the award-winning animation Kill It and Leave This Town by Mariusz Wilczyński, shown widely at film festivals, including Berlinale.

In 2017, Rubik accepted the role of Creative Consultant and Ambassador for Parley and works with the organization on global campaigns to life about ocean awareness and sustainability.

Together with Massive Attack, she worked on "Home of the Whale (Mayday Mix)", a track created to connect people to the oceans.

As Rubik stated in her interview for British Vogue in January 2021, "In 2020, the Polish government is doing its best to censor and ultimately ban sex education.

She was also a speaker at the Nairobi Summit, part of the International Conference on Population and Development (ICPD), with a presentation entitled "Innovative Partnerships: Harnessing Creative Industries to Tackle Stigma and Taboo".

She was recognized for her "courageous use of free speech" in her advocacy for women's rights and fight for youth access to sexual education in Poland.