Anjasmara began his career as a model and then starred in the soap opera Romi and July with his then-wife Dian Nitami.

[1] Prasetya met his wife, Dian Nitami, during modelling and soap opera activities.

Photos featuring nude pictures of Anjasmara with model Isabel Yahya were considered pornographic.

He was first seen on national television playing in "Hati Seluas Samudra" with Elma Theana and Jeremy Thomas.

His role as a stupid and funny man in the soap opera Si Cecep resulted in him winning the SCTV Award, in the Most Popular Actor category.