[9] Mohindra's television acting career began in an episode of ITV's long-running soap opera Coronation Street in 2005, where she played Dev Alahan's daughter Shareen after being turned down for another, larger role.

Mohindra played her first regular role as aspiring journalist Rani Chandra in the Doctor Who spin-off series The Sarah Jane Adventures (2008–2011) on children's television channel CBBC.

[12] Mohindra played a leading role in four 15-minute episodes of the BBC iPlayer romcom My Jihad (2014–2015),[13][14] described as "a tender and funny love story exploring the unfolding relationship between a young Muslim couple".

[20] The same year, she starred alongside Tom Riley in the ITV crime drama Dark Heart and guested in DC's Legends of Tomorrow as magical shapeshifter Charlie.

[22] Her stage work includes David Hare's Behind the Beautiful Forevers (2014)[23] and Shahid Nadeem's Dara (2015), both professionally recorded and broadcast through National Theatre Live, as well as Oscar Wilde's The Importance of Being Earnest (2012)[24] and Michael Frayn's Noises Off (2019).

[17] During COVID-19 pandemic, she made her writing debut with a short film called The People Under the Moon (2020), produced entirely during lockdown and starring Gwilym Lee as a medic who joins a dating app.

[33] In 2021, she appeared alongside Suranne Jones in Tom Edge's Vigil, playing Tiffany Docherty, the medical officer on board a nuclear submarine which becomes the subject of a murder investigation.

[36] In the series she played Archie, who recruits Paapa Essiedu's character George into a secret organisation that has the power to turn back time if the world is threatened by extinction.