[10][1] After participating in India's Best Cinestars Ki Khoj (2007–09), Lokhande bagged the lead role of Archana Deshmukh in Ekta Kapoor's daily soap Pavitra Rishta.

[12][13] Pavitra Rishta took a generation leap in 2013 and Lokhande also began playing Archana's granddaughter Ankita Karmarkar, opposite Karan Veer Mehra, until the series ended in 2014.

[14][15] Lokhande participated in Jhalak Dikhhla Jaa 4, where she was ranked 5th[16] and Comedy Circus ka Naya Daur.

[17][18] After a two-year hiatus from acting and her separation from Rajput, there were reports that Lokhande was set to make her film debut in Sanjay Leela Bhansali's period drama Padmaavat (2018).

[22] In 2018, Lokhande announced that she would make her film debut in the role of Jhalkaribai, a warrior in Krish and Kangana Ranaut's joint directorial venture Manikarnika: The Queen of Jhansi, an epic drama based on the life of Rani Lakshmi Bai.

[23][7] Bollywood Hungama noted, "Lokhande as Jhalkari Bai is excellent and leaves a tremendous mark in her limited screen time.

[25][26] The film was released prior to the shutdown of theatres owing to the COVID-19 pandemic in India, which affected the box office performance.

"[27] Lokhande reprised her role as Archana Deshmukh in the web series Pavitra Rishta: It's Never Too Late along with Shaheer Sheikh from 2021 to 2022.

"[29] In February 2022, Lokhande participated in StarPlus' Smart Jodi with her husband, Vicky Jain, subsequently becoming the winner of the season.