Through her work serving the poor in schools and as a nurse, Shorb helped to break down anti-Catholic prejudice.
[5][6] Once Shorb arrived with Sisters Blandina Davaux and Loyola Ritchie, they began caring for orphaned girls.
[5] By March 1843, the Great and General Court granted them a charter as the St. Vincent's Orphan Asylum.
[5] When the asylum was too small to take in more children, she organized a fair that raised $10,000 in two weeks.
[7][5][8] In 1866, the Sisters of Charity founded the St. Mary's School and Asylum at what was formerly the Norfolk House in Dedham, Massachusetts.