She appeared as Donna Anna at Drury Lane in a version of Don Giovanni in English.

Their troupe visited both Montreal and Toronto in Canada with W. H. Latham of the Theatre Royal in Drury Lane starting in 1839 and continuing over the next ten years.

They sang excerpts from a number of operas including La Sonnambula, Il Matrimonio Segreto, and La Gazza ladra[4] The role that she was best known for was Arline, the lead role in Balfe's ballad opera The Bohemian Girl.

[5] Seguin's role within the company included directing rehearsals and settling disputes between the players.

[7] The Seguin operatic troupe which had initially consisted of four to six singers went out of fashion in the late 1840s when audiences wanted their operas not in English but in the original language.

[2] Anne Childe Seguin is valued because she was the first English opera singer to make America her home.