[1] Ann was born in April 1776 near the village of Llanfihangel-yng-Ngwynfa, six miles (10 km) from the market town of Llanfyllin in the former county of Montgomeryshire (now in Powys).
After the deaths of both her parents, she married Thomas Griffiths, a farmer from the parish of Meifod and an elder of the Calvinistic Methodist church.
These were preserved and published by her mentor, the Calvinistic Methodist minister, John Hughes of Pontrobert, and his wife, Ruth, who had been a maid at Ann Griffiths' farm and was a close confidante.
Her hymn Wele'n sefyll rhwng y myrtwydd (Behold, standing between the myrtle trees) is commonly sung in Wales to the tune Cwm Rhondda.
[4] The Ann Griffiths Memorial Chapel in Dolanog, Powys, is named after her and has a carved corbel head based on contemporary descriptions of her.