[4] She worked as a lay therapist with psychedelic substances such as MDMA and 2C-B in therapeutic settings while these drugs were still legal.

[7] In her writings she stressed the potential of these drugs from a Jungian psychoanalytic perspective, as well as their use in combination with hypnotherapy.

[7] They developed a systematic way of ranking the effects of the various drugs, known as the Shulgin Rating Scale, with a vocabulary to describe the visual, auditory and physical sensations.

[citation needed] According to her daughter, Shulgin had been in ill health because of chronic obstructive pulmonary disease.

Shulgin died July 9, 2022, at her and her late husband's San Francisco Bay Area residence.