Anna Diogenissa was born in the Byzantine capital Constantinople the year after the death of her father Constantine Diogenes at Antioch in 1074.
[citation needed] Her paternal grandparents were Romanos IV Diogenes (r. 1068–1071) and Anna of Bulgaria.
It is not recorded when Anna married Uroš I, the Serbian Grand Prince, who reigned from ca.
It most likely took place during Urošʻs captivity in Byzantium, where he had been sent as a hostage by his uncle Vukan following the capture of Lipljan in 1094 by the troops of Alexios I Komnenos.
Uroš is credited with having unified most of the Serbian territories after retaking them from Byzantine occupation.