[3] Her mother Irene (née Roarke) is a nurse and her father Warren is a pharmacist and the retired Director of Pharmacy at South Oaks Hospital in Amityville, New York;[4][5] he accompanied her to the 2019 Emmy Awards show.
[8] Drezen is an editor at large of the feminist humor site Reductress and has co-written the book How to Win at Feminism: The Definitive Guide to Having it All—And Then Some!
[19] In 2019, Drezen began hosting the podcast Scary Stories to Tell on the Pod with writer Andrew Farmer,[20] was a guest on Drunk Women Solving Crime,[21] and performed on The Late Late Show with James Corden on 24 September 2019[22] At the 2019 Edinburgh Festival Fringe, Drezen premiered Okay, Get Home Safe, a one-woman show inspired by her obsession with true crime podcasts.
[24] In 2021, Freeform ordered an animated series[25] created by Drezen, which she executive produces alongside Greg Daniels, Mike Judge, and Monica Padrick.
[26] Annie Murphy, John Cho, Christine Baranski, Kiersey Clemons, Amy Hill, and Stephen Root led the voice cast.