She is known for co-creating and starring as Anna Kone on Hulu's original TV comedy series PEN15, alongside Maya Erskine.

[4] During her junior year at NYU, she attended an international experimental theater program in Amsterdam.

[5][6] Konkle started her career working on student films while at the New York University and in experimental theater.

During the first decade of her career, she appeared in small roles in TV shows such as New Girl, Shameless and Ramy.

In 2019, Konkle co-created with Maya Erskine and Sam Zvibleman Hulu's original TV comedy series PEN15.