Princess Anna Petrovna Lopukhina (Russian: Анна Петровна Лопухина; 8 November 1777 – 25 April 1805) was a royal mistress to Emperor Paul of Russia.

When Paul ordered her family to be brought to Saint Petersburg, the Empress ineffectually attempted to interfere and sent an angry letter to Lopukhina pressing her to stay at home.

After Anna was brought to the capital, the Emperor appointed her father General Procurator[3] and made him Prince with the title of His Serene Highness.

All things considered, Lopukhina's influence on the tsar's irascible character is reckoned to have been beneficial, although the Emperor's constant attention seemed to importune her so much that in 1799 she asked his permission to marry a childhood friend, Prince Pavel Gagarin.

Anna's body was brought back to the Russian capital, where her tomb may be seen in the St Lazarus Church of the Alexander Nevsky Lavra.