Vaiani worked alongside and collaborated with many artists, such as Virginia da Vezzo, who was also a part of the Academia di San Luca.

[5] Other collaborative fresco pieces include the Agony in the Garden, the Flagellation, the Crowning with Thorns, and the Road to the Calvary.

One of Vaiani's most famous paintings was the Madonna and Christ Child with John the Baptist and Cherubs.

She contributed to documentary engraving collections such as the De Florum Cultura and the Galleria Giustiniani.

[6] Vaiani was one of the artists who contributed copper-plate etchings in 1633 to illustrate Giovanni Battista Ferrari's De Florum Cultura, which was based on Barberini's botanical garden.

[7] De Florum Cultura can be found in the collection of the Metropolitan Museum of Art, and other institutions.