[1] Winning a Fulbright scholarship to study in Italy, Moffo became popular there after performing leading operatic roles on three RAI television productions in 1956.

After graduating from Radnor High School, Anna turned down an offer to go to Hollywood and instead attended the Curtis Institute of Music in Philadelphia, where she studied with Eufemia Giannini-Gregory, sister of soprano Dusolina Giannini.

In 1954, on a Fulbright scholarship, she left for Italy to complete her studies at the Accademia Nazionale di Santa Cecilia in Rome where she was a pupil of Mercedes Llopart and Luigi Ricci.

Shortly after, still virtually unknown and little experienced, she was offered the challenging role of Cio-Cio San in an Italian television (RAI) production of Madama Butterfly.

She appeared as Zerlina in Don Giovanni, at the Aix-en-Provence Festival and made her recording debut for EMI as Nannetta (Falstaff) under Herbert von Karajan, and as Musetta in La bohème with Maria Callas, Giuseppe Di Stefano and Rolando Panerai.

She performed at The Metropolitan Opera for seventeen seasons in roles such as Lucia, Gilda, Adina, Mimì, Liù, Nedda, Pamina, Marguerite, Juliette, Manon, Mélisande, Périchole, and the four heroines of Les contes d'Hoffmann.

In the late 1950s, she recorded Susanna in Le nozze di Figaro, opposite Elisabeth Schwarzkopf and Giuseppe Taddei, conducted by Carlo Maria Giulini; and recitals of Mozart arias with EMI.

During that period she also made several appearances on American television, while enjoying a successful international career singing at most major opera houses around the world (Stockholm, Berlin, Monte Carlo, Mexico City, Buenos Aires, etc.).

[5] Later that year Franchi and Moffo collaborated in recording excerpts from Die Fledermaus with the Vienna State Orchestra and Chorus conducted by Oskar Danon.

After retiring from singing Moffo remained active as a board member of the Metropolitan Opera Guild and by hosting several tributes and giving occasional masterclasses.