She is one of the four regular hosts of the podcast No Such Thing as a Fish alongside Dan Schreiber, Andrew Hunter Murray and James Harkin.

[3] Her paternal grandfather, Władysław Ptaszynski, was a Polish officer who spent time in a prisoner of war camp in Russia.

[5][6] Ptaszynski has been one of the four regular hosts of the podcast No Such Thing as a Fish since it was launched as a spinoff of the BBC quiz show QI in March 2014.

[17] Ptaszynski was the curator for the 17th series of the Radio 4 show Museum of Curiosity, which she co-hosted with its creator John Lloyd.

In July 2024, Ptaszynski and fellow No Such Thing As a Fish host James Harkin released the first episode of their podcast Quite a Good Sport.