Anna Regina Secondary School, (abbreviated as ARSS) is a secondary school located in Anna Regina, Pomeroon-Supenaam, Essequibo Coast, Guyana.

In 2013, Anna Regina Secondary School was the top school of the Caribbean, with a student achieving (19 grade ones).

[citation needed] In 2018 a student of Anna Regina secured 21 passes,[2] and in 2019 another obtained 19 grade ones at the Caribbean Secondary Education Certificate examinations.

It was established to facilitate students (who wish to study at the school) from Region 1, 2, 7, 8 & 9.

Students are provided with free meals i.e. breakfast, lunch and dinner and a few snacks at night.