[14] Rezan was interested in the arts from an early age and decided to be an actress after watching Greek movies, musicals, Disney films, and comedies.

[3][16] The following year, she starred in The Hall of Fame of the Moon, which premiered at the Greek National Opera and was produced by Cyprus' Ministry of Culture.

[12] As a teenager, her articles, which centered on love, therapy, films, and musicians such as David Bowie, Nick Cave, and The Cure, were published in indie magazines.[which?

[2][18] That year, she also appeared as Svetlana in the Greek comedy The Red Room, where she spoke Russian; starred in a TV adaption of Farewell Anatolia as Artemitsa; and performed in the rock opera The 300 Spartans on their world tour.

[18] Her feature directorial debut My People, which she wrote, directed, produced, and narrated, is a feature-length documentary about Jews in Greece & the Greek Resistance movement during World War II.

[33] In January 2023 the Order of AHEPA Bergen Knights Chapter #285 hosted the New Jersey Premiere of "My People," to honor the Holocaust Remembrance Day as well as Rezan for promoting Hellenism across the world.

[37][38] In October 2024 she is filming in Germany alongside Eric Roberts, portraying the lead role of “Nea” in sci-fi action franchise “City Rush 4” that is set to be released in 2025.

[5][3] The track was produced at Equinox Studios in Luxembourg and aired for the first time in the United States on the CBS radio show Zodiac Divas in 2013.

"[42] "My Summer Night," a Latin pop ballad duet with Barbara Sassari, came out in 2017,[42] as did her cover of Mikis Theodorakis' "The Honeymoon Song" in the style of the Beatles.

[6][43][44] In November 2023 she collaborated with Julio Iglesias and her cover of "Baila Morena" featuring Taavi Vartia was released by Universal Music Group[37][38] In 2013, Rezan was a special guest at the fourth J'adore la mode Gala charity fashion show in Philadelphia benefitting the organization Evoluer House, which empowers young women through applicable skill-building programs.

[41][2][47] Also in 2013, she appeared in Constantinos Isaias' public service announcement "We Love Cyprus" and her 2015 cover of "Happiness Is a Warm Gun" was part of a PSA to raise awareness about breast cancer.

[52] Rezan made optimistic remarks regarding the 2023 SAG-AFTRA strike which she supported actively.She said that "When people realise the great power that comes from unity, is always a big win for us all".

[53] Rezan is largely private about her personal life[54] but has made a concerted effort to be open about her struggles with depression, panic attacks, and anxiety and her recovery journey.

[56] In 2009, she was thought to have dated The Durrells actor Alexis Georgoulis;[57] in 2010, her Show Bitch co-star Nassos Papargyropoulos;[58] and in 2011, Panagiotis Bougiouris.