She married on 2 February 1525 in Szczecin Duke Barnim XI of Pomerania (1501–1573).

On the occasion of their marriage, Barnim concluded a defensive alliance with her father.

In exchange for her dowry of 12000guilders Anna was promised the city and district of Stolp as her Wittum.

Anna died in 1568 and was buried in the Church of St. Otto in Szczecin.

She felt that he put her husband at a disadvantage in the government of Pomerania and that George's intent to marry Margaret of Brandenburg was undermining her own position.