At the time of Anna's marriage, Albert Achilles held all the Franconian possessions of the Hohenzollerns.

In 1473, Anna agreed to a new House law, which made Mark Brandenburg indivisible but allowed the Franconian possessions to be shared among several sons.

Albert Achilles specified in his will that Anna was entitled to income and residency in Neustadt an der Aisch, Erlangen, Dachsbach, Baiersdorf and Liebenow.

Anna survived her husband by 26 years and resided mostly in Neustadt an der Aisch, where she maintained a relatively luxurious court.

Anna was constantly pregnant during much of her marriage to Albert Achilles, giving birth to thirteen children in just eighteen years.