On 12 February 1548 Sabina married Elector John George of Brandenburg (1525–1598) in Ansbach.

The day before the wedding ceremony, she solemnly renounced her possible paternal inheritance.

Here Sabina cared for her own children and also for her stepson Joachim Friedrich, who later became Elector of Brandenburg.

After Sabina's husband became Elector in 1571, she had an influence on religious affairs and was a patron of churches and schools.

She supported the sick and the poor and had regular personal contact with the doctor Leonhard Thurneysser.