Van Borselen had been knighted in 1426, and owned numerous manors on the island of Walcheren in Zeeland (Brigdamme, West-Souburg, Oost-Souburg, Sint-Laurens, Popkensburg, Koudekerke, Zoutelande, Kleverskerke, Grijpskerke, Meliskerke, and Ritthem).

Anne and her husband founded villages and financed the construction of churches such as the ones in Sommelsdijk (1464) and Bruinisse (1466), working together with other landowners.

He was the younger son of Adolph I, Duke of Cleves (1373–1448) and his consort, Mary of Burgundy (1393–1466), Anne's paternal aunt.

In 1498 she transferred Sint-Annaland, Hannevosdijk and Moggershil to her half-brother Baudouin of Burgundy, Lord of Fallais (1446–1508), another illegitimate child of Philip the Good.

The castle in West-Souburg and the Zeeland polders were inherited by her (also illegitimate) half-brother, Philip of Burgundy (1464–1524), a priest and Admiral of Flanders.