[1][2] In 1645, her mother remarried to Rudolf Wilhelm zu Innhausen und Knyphausen (1620-1666), a diplomat of the States General of the Netherlands with whom she had two children: Haro Caspar and Maria Elisabeth.
[1][3] In 1657, Anna van Ewsum married Carl Hieronymus von Inn- und Knyphausen (1632-1664), the brother of her stepfather.
When he died, Anna ordered a sepulchral monument for her husband and herself from the sculptor Rombout Verhulst, to be placed in the local church of Midwolde.
[1][2] In 1665 Anna remarried to Georg Wilhelm van Inn- en Kniphuisen (1635-1709), a nephew of her stepfather and her late husband.
[1][2] Anna van Ewsum is remembered as a patroness of the arts, who employed some of the best Dutch artists of the period.