It is located on the plains east of the Mount Lofty Ranges astride the Sturt Highway 110 kilometres (68 mi) from Adelaide, between Truro and Blanchetown, South Australia.

Halfway House Road is a heavy vehicle detour route that runs south from the Sturt Highway at Annadale.

[1] Annadale occupies the central part of the hundred of Anna.

Annadale was established as a private subdivision laid out by a farmer named Joseph W Vigar in 1881.

[2] Annadale is the site of the Truro Flat Airpark (ICAO: YTFA) owned by the Barossa Birdmen.