[2] Anne married the Earl of Northesk on 30 April 1748, and they had six children, all of whom survived their mother.
Lady Northesk was apparently suffering from tuberculosis and had been pronounced incurable by several doctors.
[5] Darwin considered treating her anaemia with a blood transfusion by syringe, using her friend, his neighbour Anna Seward, as a possible donor.
[6] He decided against the idea, and instead prescribed a diet of milk, vegetables and fruit, in addition to rest and fresh air, which appears to have been effective.
Lady Northesk continued to correspond with Seward, and later died in Edinburgh, in a domestic accident, after accidentally setting fire to her muslin cap.