[1][2] Edmund descended from John of Gaunt 1st Duke of Lancaster, himself the son of King Edward III of England.
Anne's mother was Grey's second wife, Catherine Herbert (died 1506) who was the daughter of William Herbert, 1st Earl of Pembroke, the second son of Sir William ap Thomas of Raglan, a member of the Welsh gentry; and Anne Devereux, the daughter of Sir Walter Devereux, Lord Chancellor of Ireland.
[3] According to historian Sir William Dugdale, in the documents written by Hussey shortly before his death in 1537, he spoke of his wife 'Anne'.
[6][7] Baroness Hussey was amongst a group of high ranking noblewomen who openly opposed King Henry VIII's proposed divorce from Catherine of Aragon.
[7] When Mary Tudor was declared illegitimate by Act of Parliament in 1533,[8] King Henry forbade anyone to call address his daughter with the title of Princess.
[10] When the Pilgrimage of Grace broke out in Lincolnshire in 1536, where Grey's husband was sheriff, he was seen to vacillate even though he had refused to join the rebels and told them to return to their home.