She is based at the High Field NMR Centre of the Lyon Institute of Analytical Sciences, where she develops novel nuclear magnetic resonance approaches to characterise solid-state materials.
She moved to the Pierre and Marie Curie University for graduate studies, where she earned a master's degree in biophysics in 1992.
[citation needed] Lesage moved to Lyon for doctoral research, where she used NMR to investigate the COL1-NC1 junction.
[1] In 1994, Lesage joined the French National Centre for Scientific Research, where she started working at the École normale supérieure de Lyon.
[3] The technique has been improved since the 1990s, including the development of advanced equipment and design of stable sources of polarisation (organic radicals).