From 1954 to 1957 she was educated as a ceramist at the Norwegian National Academy of Craft and Art Industry in Oslo, with Jens von der Lippe as supervisor.
From 1959 to 1963 she was engaged as a designer at the Stavangerflint AS earthenware factory in Stavanger, Norway where she served as a member of the company's artistic staff under the directorship of Kåre Berven Fjeldsaa.
While employed at Stavangerflint, Anne Lofthus created designs for ceramic tableware and items for decoration or special occasions.
Her most famous designs for tableware are Tiril, Vinge and the children's set Du som metter liten fugl (Lord you feed the little bird).
Her style as an artist is usually easily recognizable by her references to Norwegian Folk Art, such as the décor-objects Stolt Margit and Folklore both of which are based on inspiration from the cultural heritage of the Telemark region.