Several composers dedicated sonatas to her, including Johann Schobert, Luigi Boccherini, Charles Burney, Ernst Eichner, and Henri-Joseph Rigel.

The piano music written for her own performance is virtuosic, incorporating new keyboard techniques and sonorities, along with a number of innovations usually associated with later pianist-composers such as Czerny and Liszt.

When Benjamin Franklin arrived in Paris in 1777 as ambassador from the American colonies, he lived near the Brillon residence and was a welcome guest at her distinguished salon, which he described as 'my Opera', where there are 'little Concerts' with music and singing.

The set was dedicated to Anne Louise Brillon: Madame, I have never before composed for the keyboard; I heard you play on that instrument, and then I wrote these sonatas; the homage that I offer you through them is, simultaneously, a fitting tribute, and one of reconnaissance; you have inspired them, and you embellish them.

She likewise composes, and she was so obliging as to play several of her own pieces both on the harpsichord and pianoforte accompanied with the violin by M. Pagin, who is reckoned in France the best scholar of Tartini ever made.

1775-1783: 1777: 1779-1785: Madame Brillon appears in the children's book Ben and Me (1939) by Robert Lawson, where she is the subject of an elaborate, humorous full-page illustration.

"In the Salon of Madame Brillon: Music and Friendship in Benjamin Franklin's Paris", The Raritan Players, directed by Rebecca Cypess.