She had other small roles in the early 1990s, being directed by Alain Resnais and in Jean-Paul Rappeneau's Cyrano de Bergerac with Gerard Depardieu.

Her return to cinema saw her gain commercial and critical success, notably in films directed by François Ozon.

The next year she starred alongside Charlotte Rampling in Ozon's psychological thriller Swimming Pool, a role which again garnered her nominations and prizes.

Other notable films she has appeared in include Peter Pan, as Tinkerbell, and the crime thriller Mesrine: Public Enemy No.1.

Sagnier plays Claire in the French thriller series Lupin, which premiered on Netflix in January 2021.