She is best known for writing and producing the 2010 film Winter's Bone with her frequent collaborator Debra Granik.

[1] In New York, Rosellini began to collaborate with Debra Granik, who at the time was writing a feature film and sought a producer.

The project eventuated as Down to the Bone, released in 2004, which was produced by Rosellini and co-written and directed by Granik.

[3] Rosellini went on to produce the 2007 horror film Cthulhu before returning to work with Granik on a second feature together.

After reading Daniel Woodrell's book Winter's Bone, Rosellini and Granik decided to write a screenplay based on the manuscript together.