Through her mother, Anne was a descendant of Thomas of Woodstock, the youngest son of King Edward III of England and Philippa of Hainault.

[10] She refused to bear Catherine's train, and allegedly physically tried to push her out of her place at the head of their entrances and exits at court.

The Duchess, who was described as a "violent woman", wielded considerable power for a short time, which later would reflect negatively on her husband's reputation.

[16] According to the Imperial ambassador Jean Scheyfve, Anne Seymour had made daily visits to the house of the de facto new ruler, John Dudley, Earl of Warwick, who soon allowed Somerset to rejoin the Privy Council.

The Duchess of Somerset and the Countess of Warwick then arranged a marriage between their respective eldest daughter and son, Anne Seymour and John Dudley.

[17] Somerset fell again into disgrace in October 1551, when he was arrested on charges of conspiring against Warwick, who had recently been created Duke of Northumberland.

[19] After Mary I's accession in July and the attainder of the Duke of Northumberland she was allowed to choose from the Dudley family's confiscated household stuffs.

Anne Seymour died at Hanworth Palace,[22] Middlesex, on 16 April 1587, and was buried in Westminster Abbey,[23] where her tomb with its painted effigy can be viewed.

In her will, Anne Seymour bequeathed to her "daughter of Hertford" (her daughter-in-law), Lady Katherine Grey, a fair tablet or locket "to wear with antique work on one side, and a rose of diamonds on the other".

Her collection included a chain of gold pomander beads with "true-loves" or love knots of pearl and a red taffeta purse containing two pieces of unicorn horn.

She was referenced in the show Becoming Elizabeth when Jane Grey attempted to console Catherine Parr, who had just learned that she was pregnant, that the Lord Protector's wife had survived 10 pregnancies.