[3] She exhibited regularly at the Royal Academy from 1784 to 1818 and was a close friend to members of Georgian high society, including Horace Walpole and the politician Charles James Fox.

In 1766 at the age of 17, Damer was sketched by Angelica Kauffman in the character of the goddess Ceres, a work now held at St Mary's University, Twickenham.

In 1775, Anne was included in a painting titled The Three Witches from Macbeth by Daniel Gardner (c. 1750 – 1805), which can be found in the National Portrait Gallery, London.

The work shows her next to other ladies of high society: Elizabeth Lamb, Viscountess Melbourne and Georgiana, Duchess of Devonshire.

This money allowed her to be financially independent, and continue her artistic career, whilst maintaining a full social life, on a more intellectual plane than that of her earlier married years.

Anne used Strawberry Hill as her country house until 1811, which she maintained alongside her central London home in Upper Brook Street.

[3] The development of Anne Seymour Damer's interest in sculpture is credited to David Hume (who served as Under-Secretary when her father was Secretary of State, 1766–1768) and to the encouragement of Horace Walpole, who was her guardian during her parents' frequent trips abroad.

According to Walpole, her training included lessons in modelling from Giuseppe Ceracchi, in marble carving from John Bacon, and in anatomy from William Cumberland Cruikshank.

Her subjects, largely drawn from friends and colleagues in Whig circles, included Lady Melbourne, Nelson, Joseph Banks, George III, Mary Berry, Charles James Fox and herself.

Her guardian and friend Horace Walpole was a significant figure, who helped foster her career and on his death left her his London villa, Strawberry Hill.

She also moved in literary and theatrical circles, where her friends included the poet and dramatist Joanna Baillie, the author Mary Berry, and the actors Sarah Siddons and Elizabeth Farren.

She frequently took part in masques at the Pantheon and amateur theatricals at the London residence of the Duke of Richmond, who was married to her half-sister, Lady Mary Bruce[9] A number of sources have named Damer as being involved in lesbian relationships, particularly relating to her close friendship with Mary Berry, to whom she had been introduced by Walpole in 1789, and with whom she lived together in her later years.

Even during her marriage, her likings for male clothing and demonstrative friendships with other women were publicly noted and satirised by hostile commentators such as Hester Thrale[10] and in the anonymous pamphlet A Sapphick Epistle from Jack Cavendish to the Honourable and most Beautiful, Mrs D— (c.