In June 1423 at Troyes, Anne married John of Lancaster, 1st Duke of Bedford, son of Henry IV of England, a marriage agreed by the terms of the 1423 Treaty of Amiens.

[3] Burgundy's antagonism towards the House of Valois (which caused the Armagnac–Burgundian Civil War) had been one of the leading factors in the losses faced by the French at the hands of the English.

[7] Her tomb was designed by Guillaume Vluten and, according to one historian, "ranks among the most important Parisian effigies of the first half of the fifteenth century".

Bones and other remains, found during archeological exploration of the couvent des Célestins in 1847, were identified as being those of Anne, thanks to a plaque bearing her name.

Relations between John and Philip became cool, leading to the 1435 peace negotiations between Burgundy and Charles VII, the exiled king of France.