It has been Canada's longest-running musical,[1] performed annually from its opening in 1965 until 2019, with the planned 2020 and 2021 productions cancelled due to the COVID-19 pandemic.

[5] Mavor Moore, the founding artistic director of Charlottetown's Confederation Centre of the Arts, used the title song from that special in the inaugural variety performance in 1964, which was attended by Queen Elizabeth II.

It was performed every summer beginning in 1965, headlining the Charlottetown Festival at the Confederation Centre of the Arts, Prince Edward Island, making this Canada's longest-running mainstage musical.

[8] A song from the musical was part of the feature performance at the opening of the Confederation Centre of the Arts on October 6, 1964, playing to Her Majesty Queen Elizabeth II and His Royal Highness The Duke of Edinburgh as well as Prime Minister Lester B. Pearson.

An independent production opened on April 16, 1969, at the New Theatre, London, running for nine months and starring Polly James as Anne.

The tour was organized by director Walter Learning, and starred Leisa Way as "Anne", Denise Ferguson as "Marilla" and David Hughes as "Matthew".

In December 2019, EK Productions staged an immersive version in Adelaide starring Issy Darwent and directed by Benjamin Maio Mackay.

School productions typically either cut out a few tracks (Humble Pie, I'll Show Him, to name a couple) or change the key to better suit some of the more inexperienced student vocalists' ranges, as well as keep the plot fast-paced.