Annibale D'Afflitto (died 1638) was a Roman Catholic prelate who served as Archbishop of Reggio Calabria (1593–1638).

On 15 November 1593, Annibale D'Afflitto was appointed during the papacy of Pope Clement VIII as Archbishop of Reggio Calabria.

[1][2][3] On 30 November 1593, he was consecrated bishop by Alfonso Gesualdo di Conza, Cardinal-Bishop of Ostia e Velletri, with Giulio Ottinelli, Bishop of Fano, and Cristóbal Senmanat y Robuster, Bishop Emeritus of Orihuela, serving as co-consecrators.

[3] He served as Archbishop of Reggio Calabria until his death on 1 April 1638.

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