Griffin was born in New York City and relocated to the United Kingdom in 1981.
Griffin started as an experimental theatre writer and director in the 1980s, with her first notable work being Blackbeard the Pirate in 1987, at the ICA in London.
[1] In the early 1990s she worked creating animated idents for MTV.
[2][3][4][5] Griffin wrote and directed The Book Group, a comedy drama which aired on Channel 4 in the United Kingdom between 2002 and 2003, and ran for two series.
[6] In 2011, Griffin directed two episodes of the Channel 4 comedy-drama series Fresh Meat.