Annihilus was created by writer Stan Lee and artist Jack Kirby, and was notably featured in the "Annihilation" event.

Annihilus first encounter the Fantastic Four when they enter the Negative Zone seeking anti-particles needed to treat Sue's cosmic ray-related pregnancy complications.

Annihilus's minions capture the heroes, but they escape and temporarily steal his Control Rod to harness its antimatter particles.

[7][8] Annihilus was challenged by a research scientist, Janus the Nega-Man, who developed a module capable of harnessing antimatter energy within the Negative Zone.

[11] Sensing great power within Franklin Richards, Annihilus abducted him, along with the Fantastic Four, Medusa, Wyatt Wingfoot, and Agatha Harkness into the Negative Zone.

[19] Annihilus began leading the Annihilation Wave, a fleet of Negative Zone battleships, ostensibly claiming to have the goal of conquering the universe.

His forces destroy the Kyln, an intergalactic power station and maximum security prison, and the planet Xandar, headquarters of the Nova Corps.

[25] Drax and the Silver Surfer free Galactus, who destroys the Annihilation Wave while Nova battles and kills Annihilus.

They discover the infant Annihilus and his Cosmic Control Rod have been placed under the care of a lesser lord of the Negative Zone, Catastrophus.

Talon kills Catastrophus and seizes the Rod, before calling out to the infant Annihilus and asking it to remember in the future that he had spared the creature's life.

[30][31][32][33] Annihilus uses regenerative surgery to revive the Human Torch, turning him into a gladiator when he refuses to reopen the portal from the Negative Zone.

As part of a plan to orchestrate an event known as the "War of Four Cities", Richards offers to open a massive portal between the Negative Zone and Earth, allowing the Annihilation Wave to pass through.

[35] Johnny Storm learns of the plan and enlists the Inhumans Light Brigade in an uprising, attacking Annihilus' forces as they prepare to cross over.

Seeking to return to a more impressive size, he abducts Bruce Banner and harnesses his power to mutate into a monstrous form.

Using the Nega-Bands to open a portal out of the Negative Zone, Annihilus plots to destroy Earth and the rest of the universe by using a powerful energy cannon.

[4][45] Though not always engaging himself in direct combat, Annihilus has proved to be a very formidable opponent, and was able to defeat the Thing,[46] Thor, Nova Prime, Quasar, and Blastaar in individual fights with relative ease.

This version is a member of a resistance against Blastaar who was previously rendered amnesiac, assumed a humanoid form, and took the identity of Ahmyor.

This version is the leader of the Bottled Hive of Annihilation, a race of small but powerful insects from the Negative Zone.

He is the ruler of a space station composed of the remains of alien spaceships that orbits a dying red dwarf star.

After learning of the Ultimate Universe, he attempts to travel to it to escape the Negative Zone's eventual decay, only to be killed by the Fantastic Four.