She has represented her country a total of 382 times in which she won six European titles, was the runner-up at 2010 and 2014 World Championships, won silver medals at the 2008 Summer Paralympic Games in Beijing and 2016 Summer Paralympics in Rio de Janeiro, and won a gold medal at the 2012 Summer Paralympics in London, for which President Joachim Gauck awarded the team Germany's highest sporting honour, the Silbernes Lorbeerblatt (Silver Laurel Leaf).

Following the Rio 2016 Paralympic Games, Zeyen retired from wheelchair basketball to pursue alternative sporting challenges as an individual athlete.

[3] In September 2008, Zeyen participated in the 2008 Summer Paralympics in Beijing, but Germany was beaten in the gold medal match by the United States team,[5] which contained three of her former teammates from the University of Alabama, Stephanie Wheeler, Mary Allison Milford and Alana Nichols.

[13] They defeated the Australians 58–44 in front of a crowd of over 12,000 at the North Greenwich Arena to win the gold medal,[12] the first that Germany had won in women's wheelchair basketball in 28 years.

[14] The German team lost the European Championship to the Netherlands before a home town crowd of 2,300 in Frankfurt in July 2013 by a point, 56–57.

As a result of this impressive first competitive season, Zeyen was selected for the German National team to compete at the 2019 Para-cycling Road World Championships in Emmen, Netherlands.

Zeyen was selected to compete in the individual time trial and road race as well as the mixed relay team alongside Vico Merklein (H3M) and Bernd Jeffre (H4M).

Due to COVID-19 pandemic, there were no sanctioned races in 2020 however Zeyen returned to competition in June 2021 at the UCI Para-cycling Road World Championships at the Circuito EsTirol in Cascais, Portugal.

She competed in the team relay along with Vico Merklein (H3M) and Bernd Jeffre (H4M) as well as the individual time trial and road race (H3W).

Zeyen completed the 16.8 km course in a time of 28 minutes and 59 seconds taking the silver medal behind Francesca Porcellato from Italy.

Introduced in 1926, the Golden Book  is a time-lapse; recording the extent to which the Federal Republic of Germany has gained international renown by including well-known personalities from around the world and locally who have shaped the city and contributed to Bonn's reputation.