Cacace made his professional debut on 25 February 2012, scoring a first-round technical knockout (TKO) victory over Ben Wager at the Emerald Roadhouse in Belfast, Northern Ireland.
[8] He gained decision victories over Zsolt Nagy in March[9] and Osnel Charles in October 2013,[10] followed by wins over Dawid Knade by TKO in September[11] and Simas Volosinas by PTS in December 2014.
In what was a close competitive fight, Cacace suffered the first defeat of his professional career , losing by unanimous decision (UD) over twelve rounds, with the judges' scorecards reading 116–113, 116–114 and 115–113, all in favour of Ward.
[24][25] Cacace defeated two-time former featherweight world champion Josh Warrington by unanimous decision at Wembley Stadium on 21 September 2024.
[26][27] Cacace's belt was not on the line as the IBF did not recognise Warrington as a challenger due to his inactivity in the super-featherweight division, with the governing body announcing he would be stripped of the title had he lost the contest.