In 2010, Warrington won all three of his fights, defeating Danny McDermid (0-1), John Riley (0-0) and Youssef Al Hamidi (7-27-2), winning all of his four-round contests by points decision.
By the end of 2011, Warrington maintained his undefeated record with wins over Steve Gethin (11-56-3), Chris Riley (3-3-2), Marc Callaghan (19-21-1), Dougie Curran (5-8-1) and Ian Bailey (7-8), all by points decision.
He won by unanimous decision over 10 rounds (scorecards of 100–91, 100–91, 100-90) when headlining a show at the Town Hall in Leeds.
On 2 November, Warrington won the vacant Commonwealth featherweight title after he defeated the previously undefeated Hull-born prospect Samir Mouneimne by 12th-round stoppage in a 12-round contest.
Promoter Eddie Hearn said: "Josh is the biggest ticket seller in the country right now, and we have an opportunity to do something very big in Leeds.
On 4 October, Warrington won the vacant EBU European featherweight title after he defeated Italy's Davide Dieli (15-3) by fourth-round stoppage in a twelve-round contest.
"[24] Later that month, Warrington vacated his EBU European featherweight title after suffering a slight injury.
[25] On 22 June, Matchroom Boxing announced that Warrington would defend his WBC International and Commonwealth featherweight titles against Australia's Joel Brunker (28-1) at the First Direct Arena in Leeds on 5 September.
Promoter Eddie Hearn said of the fight: "Josh is hunting a summer clash with IBF champion Lee Selby, so he cannot afford any slip-ups against Japanese banger Amagasa."
[29] On 14 June, Matchroom Boxing announced that Warrington would make the third defence of his WBC International featherweight title against Patrick Hyland (31-2), headlining a show at the First Direct Arena in Leeds on 30 July.
Warrington's promoter and Matchroom managing director Eddie Hearn said in a statement "we did not share the same plans as his team and decided not to make any further offers.
[38] Warrington defeated Martinez by a majority decision over 12 rounds, with scorecards of 116-112 (twice) and 114–114, in the third defence of his WBC International title.
Warrington was accompanied to the ring by ex Leeds United player Lucas Radebe whilst band Kaiser Chiefs performed live.
On 15 June 2019, Warrington had his second title defense against domestic rival and IBF #1 contender Kid Galahad in his hometown of Leeds.
[47] In a messy bout, with a lot of holding and clinching from both sides, Warrington proved to be the aggressor more often than his counterpart, which was sufficient to edge the victory and retail his world title.
[48] Warrington faced Mauricio Lara, a relatively unknown 22-year-old Mexican prospect, on 13 February after over a year of inactivity.
[49] Warrington started off the fight slower than usual, and in the fourth round, he was hurt by a left hook before ultimately being knocked down.
[52] It was announced on 14 July 2021 that Warrington and Lara would face each other in a rematch on 4 September at Emerald Headingley Stadium in the former's hometown of Leeds.
[53] The fight ended in a technical draw after 2 rounds, after Lara was badly cut above his left eye due to a head clash.