Anthony James DeSclafani (born April 18, 1990) is an American professional baseball pitcher who is a free agent.

He has previously played in Major League Baseball (MLB) for the Miami Marlins, Cincinnati Reds, and San Francisco Giants.

[9] On November 19, 2012, the Blue Jays traded DeSclafani, Adeiny Hechavarria, Henderson Álvarez, Yunel Escobar, Jeff Mathis, Justin Nicolino, and Jake Marisnick to the Miami Marlins, receiving Mark Buehrle, Josh Johnson, José Reyes, John Buck, and Emilio Bonifacio in exchange.

[8] He was optioned back to the New Orleans Zephyrs of the Triple–A Pacific Coast League on August 16, with the return of Henderson Álvarez.

[13] During a game against the Milwaukee Brewers on September 11, DeSclafani was ejected for the first time in his MLB career after intentionally hitting Carlos Gómez with a pitch.

[12] After the season he pitched for Salt River in the Arizona Fall League and was 1–0 with a 2.67 ERA in 27 innings, and was second in the AFL in strikeouts.

[12] On December 11, 2014, the Marlins traded DeSclafani and Chad Wallach to the Cincinnati Reds in exchange for Mat Latos.

[17] He was later diagnosed with a sprained ulnar collateral ligament of the elbow (UCL),[18] and began the season on the disabled list.

[25] In 2019, Desclafani played a full season, pitching third in the Reds' starting rotation behind Luis Castillo and Sonny Gray.

[10] On July 23, 2020, one day into the quarantine-shortened season, the Reds placed Desclafani on the 10-day injured list with a strained back muscle.

[27] In the 2021 regular season, he was 13–7 with 2 shutouts (tied for the National League lead) and a 3.17 ERA in 31 starts covering 167.2 innings.

[34] On January 5, 2024, the Giants traded DeSclafani, Mitch Haniger and cash considerations to the Seattle Mariners for Robbie Ray.

[35][36] On January 29, the Mariners traded DeSclafani, Justin Topa, Gabriel González, Darren Bowen, and cash considerations to the Minnesota Twins in exchange for Jorge Polanco.