Indications for its use include sports medicine and orthopaedics (such as acute muscle strains, tendinopathy,tendinosis, muscle-fascial injuries, and osteoarthritis,[4]) dermatology (for androgenic alopecia, wound healing, and skin rejuvenation), and even proctology (for fistula en ano[5]).

It serves as a source for the delivery of growth factors and/or cells within tissue-engineered constructs, often in combination with biomaterials.

[18] A 2018 systematic review and meta-analysis of high quality studies found that PRP was beneficial for treatment of lateral epicondylitis.

A 2022 review and meta-analysis showed improved patient-rated outcomes in patients with partial rotator cuff tears.

[35][36] A 2019 meta-analysis found that PRP might be more effective in reducing pain and improving function than hyaluronic acid in knee arthritis.

[38] Platelet-rich plasma (PRP) is an emerging technique in tissue regeneration, increasingly used to enhance healing in dental and oral surgery, particularly for aging patients.

PRP is derived from the patient's blood through centrifugation, concentrating growth factors that are crucial for wound healing and tissue repair.

This inquiry reported only poor quality evidence that PRP offers any clinical benefits for treatment in acute muscle, tendon, and ligament injuries in any population.

[49] Factors that determine efficacy include number of sessions, double versus single centrifugation, age and gender, and where insertion site.

Studies have reported that intrauterine inoculation of PRP before embryo transfer can thicken the endometrium and improve reproductive prognosis.

[53] and pregnancy outcome in women treated with PRP who had a history of infertility, hormonal abnormalities, an absence of menstrual cycle, and premature ovarian failure in a single centre.

PRP used for fertility trouble increases AFC,[54] number of cleavage embryos, and improves cancellation rate in women with poor ovarian reserve.

A study combining a PRP therapy with conventional venous ulcer treatments reported improved quality of life and healing time.

"[57] A 2024 meta-analysis reported that the growth factors present in PRP are vital in the healing of diabetic foot ulcers; specifically in their closure.

[58] Platelet-rich plasma therapy is a minimally invasive procedure that may be used in aesthetic medicine to treat skin conditions such as the removal of wrinkles, the reduction of lines, and improvement of blemishes, and hair loss.

A review reported weak evidence of harm, occurring at comparable, low rates in treated and untreated people.

[62] Though not required for the process, platelets can be activated by the addition of thrombin or calcium chloride, which induce the release of the factors from alpha granules.

[72] In the 2010s, cosmetic procedures marketed under the name of "vampire facials" grew in popularity, fueled by celebrity endorsement.

[73][74] In April 2024, the CDC announced that three women who had been patients at the Albuquerque, New Mexico, VIP Spa had been diagnosed with HIV after getting such facials.

[62] In January 2011, the World Anti-Doping Agency removed intramuscular injections of PRP from its prohibitions after determining that there is a "lack of any current evidence concerning the use of these methods for purposes of performance enhancement".