He played college football at Virginia from 1995 to 1998 for head coach George Welsh, and earned All-American honors.

[1] As quarterback and safety, Poindexter led the Cavaliers to back-to-back Division 3 football championships in 1992 and 1993, defeating Matoaca High School in both finals.

[1] Poindexter was drafted by the Florida Marlins of Major League Baseball during his senior season of high school.

As a redshirt freshman in 1995, Poindexter teamed with fellow defensive back Adrian Burnim in one of the most famous plays in Cavalier history as the two stopped Florida State's running back Warrick Dunn inches from the goal line, defeating the second ranked Seminoles 32-28.

In a game against N.C. State in 1998, Poindexter made a tackle on wide receiver Chris Coleman but he twisted his left leg and tore his ACL and two other ligaments.

At the end of the 2023 regular season, PSU defensive coordinator, Manny Diaz, left to take the head coaching position at Duke.

Poindexter was then appointed as interim co-defensive coordinator for Penn State's appearance in the Peach Bowl.