The Anthony and Susan Cardinal Walke House is a historic residence on the west side of Chillicothe, Ohio, United States.

[2] The approximate construction date for the Walke House is known from local land records, which show that the value of the property rose from $5 to $223 per acre shortly after 1812.

[4] Various elements of the Federal and Classical Revival architectural styles are present at the Walke House, including the prominent front portico with its four columns.

[3] A single-story building set on an above-ground basement,[2] which in turn rests on a foundation of sandstone,[5] the house features such elements as a fanlight, multiple Palladian windows, and a hip roof.

[2] Despite some modifications made during the early twentieth century, the house remains largely as it was when it was built; the interior woodwork has been preserved, as have all exterior elements except for the roof.