It was first described by Europeans in the 1866 edition of La Belgique Horticole, where it was noted to be first collected for the houseplant trade by Gustav Wallis during his time working for Jean Jules Linden.

This impressive and sought-after Anthurium species is native to Peru, where it may be found near the Huallaga River valley, to the north of Tingo María and Juanjuí, in the regions of Huánuco and San Martín, respectively (with a number of specimens being described from the latter location).

A. regale is often found in areas where the ambient humidity is consistently high, and where temperatures remain steadily between 15 °C (59°F) and 26.6 °C (80°F).

[1][2] Anthurium regale is best known for its large, cordate leaves, which have a slight velvety texture and often display prominent white veining.

[3] Each lateral vein connects in a large "circle" around the leaf's edge, eventually all meeting at the leaf tip, where they connect with the dominant central vein.