Most antipsychotics are dopamine antagonists, and have been used in treating schizophrenia, bipolar disorder, and stimulant psychosis.

[1] Dopamine is believed to play a significant role in the pathogenesis of schizophrenia, with most effective antipsychotics blocking D2 receptors.

[1][3][5] Dopamine receptor antagonists are used in the management of a broad range of diseases and conditions such as schizophrenia, bipolar disorder, nausea and vomiting.

[1] Melatonin suppresses dopamine activity[6] as part of normal circadian rhythm functions, and pathological imbalances have been implicated in Parkinson's disease[7] They may include one or more of the following and last indefinitely even after cessation of the dopamine antagonist, especially after long-term or high-dosage use: First generation antipsychotics are used to treat schizophrenia and are often accompanied by extrapyramidal side effects.

[15][1] These drugs have fewer extrapyramidal side effects and are less likely to affect prolactin levels when compared to typical antipsychotics.