Produced by WondaGurl and Eestbound, the song peaked at number 16 on the US Billboard Hot 100 chart.

"Antidote" has since been certified septuple platinum by the Recording Industry Association of America (RIAA).

On September 3, 2015, a teaser for the "Antidote" music video was uploaded on Scott's Vevo channel.

[3] The music video features Dominican models Yaris Sanchez and Ayisha Diaz and rapper Rich Hil (with green hair).

[4][5] On November 17, 2015, in between dates on The Weeknd's "Madness Fall Tour," Travis Scott appeared on Late Night with Seth Meyers, where he performed a medley of "Antidote" and "Pray 4 Love".