The word Antigonish is of Mi'kmaq origin, possibly derived from Nalegitkoonecht meaning "where branches are torn off".

[6] In 2001, the Town of Antigonish applied to annex 1,600 hectares from the surrounding county so it could expand.

The Municipality responded that the annexation would hurt its tax base so it instead applied for a total merger, or amalgamation.

The issue was sent to the Nova Scotia Utility and Review Board, and in 2005 it was decided that amalgamation of the Town and Municipality would better serve both parties.

The board ultimately rejected the proposal for amalgamation, citing lack of public support.